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Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2

Liming Chen1, Jose E Manautou1, Theodore P Rasmussen1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.

Acta Pharmaceutica Sinica. B
|August 7, 2019
PubMed

Keywords:
3′-UTR, 3′-untranslated region5-aza-C, 5-aza-2′-deoxycytidineABCG2, ATP-binding cassette subfamily G member 2ALL, acute lymphocytic leukemiaAML, acute myeloid leukemiaAUC, area under curveBCRPBCRP, breast cancer resistant proteinEpigeneticsFTC, fumitremorgin CGene polymorphismsH3K4me3, histone H3 lysine 4 trimethylationH3K9me3, histone H3 lysine 9 trimethylationH3S10P, histone H3 serine 10 phosphorylationHDAC, histone deacetylaseHIF-1α, hypoxia inducible factor 1 subunit alphaHIV-1, human immunodeficiency virus type-1HMG-CoA, β-hydroxy-β-methyl-glutaryl-coenzyme AMDR, multidrug resistanceMDR1, multidrug resistance 1NBD, nucleotide binding domainP-gp, P-glycoproteinPhysiologic factorsPrecision medicineRISC, RNA-induced silencing complexSNP, Single nucleotide polymorphismTKI, tyrosine kinase inhibitorTat, transactivator proteinmiRNA, microRNAsiRNA, small RNA interference

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