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Updated: Jan 21, 2026
12:04
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
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Neuroendocrine Tumors in Pediatrics
Zainab Azam Farooqui1, Aman Chauhan2,3
1University of Pikeville, Pikeville, KY, USA.
Global Pediatric Health
|August 7, 2019
Summary
Neuroendocrine tumors (NETs) are rare but can metastasize. Early detection and surgical resection offer excellent outcomes for well-differentiated pediatric NETs, with new treatments available for advanced cases.
Area of Science:
- Oncology
- Endocrinology
- Pediatrics
Background:
- Neuroendocrine cells are widespread, leading to neuroendocrine tumors (NETs) in various organs.
- NETs are rare, with distinct incidence rates in adults and children, and can present with vague symptoms, often leading to late diagnosis.
- Despite indolent behavior, NETs pose risks of metastasis and significant morbidity, though long patient survival leads to high prevalence.
Purpose of the Study:
- To review the current understanding and management of pediatric neuroendocrine tumors (NETs).
- To highlight recent advancements in treating metastatic and progressive NETs.
Main Methods:
- Literature review of neuroendocrine tumors, with a focus on pediatric cases.
- Analysis of current diagnostic and therapeutic strategies for NETs.
Main Results:
- Early-stage, well-differentiated pediatric NETs have high cure rates with surgical resection.
- Advanced or metastatic NETs benefit from emerging therapies like peptide receptor radionuclide therapy, telotristat, and everolimus.
Conclusions:
- Increased awareness and early detection of pediatric NETs are crucial for optimal patient outcomes.
- Recent therapeutic advancements offer improved management options for progressive and metastatic NETs.
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