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A superparamagnetic Fe3O4-TiO2 composite coating on titanium by micro-arc oxidation for percutaneous implants
Kai Li1, Shiyu Liu2, Yang Xue1
1State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China. lan.zhang@mail.xjtu.edu.cn yonghan@mail.xjtu.edu.cn.
Journal of Materials Chemistry. B
|August 7, 2019
Summary
Superparamagnetic titanium dioxide (TiO2) coatings with iron oxide nanoparticles (Fe3O4 NPs) enhance fibroblast response and improve skin integration for percutaneous implants. This magnetic coating reduces bacterial growth and soft tissue inflammation.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Tissue Engineering
Background:
- Percutaneous implants often suffer from poor skin integration.
- Micro-magnetic fields can influence cellular responses and tissue integration.
- Titanium dioxide (TiO2) is a common material for implants.
Purpose of the Study:
- To develop superparamagnetic TiO2 coatings incorporating iron oxide nanoparticles (Fe3O4 NPs) to improve the skin integration of percutaneous titanium (Ti) implants.
- To investigate the effect of Fe3O4 NP concentration on TiO2 coating properties and biological responses.
- To evaluate the in vitro fibroblast and Staphylococcus aureus response, and in vivo skin integration.
Main Methods:
- Fabrication of superparamagnetic TiO2 coatings with Fe3O4 NPs via micro-arc oxidation.
- Characterization of surface properties (phase composition, Ca2+ release, roughness, hydrophilicity) and Fe content.
- Evaluation of in vitro fibroblast proliferation, phenotype, extracellular collagen secretion, and S. aureus response.
- Assessment of in vivo skin integration, soft tissue recession, and inflammatory reactions.
Main Results:
- Fe3O4 NPs were successfully incorporated into TiO2 coatings, reaching up to 4.41 wt% Fe.
- The incorporation of Fe3O4 endowed TiO2 coatings with superparamagnetism without altering key surface properties.
- Increased Fe3O4 content enhanced fibroblast proliferation, phenotype, and collagen secretion.
- TiO2 coatings with 4.41 wt% Fe reduced bacterial reproduction by approximately 60% and improved soft tissue integration.
Conclusions:
- Superparamagnetic TiO2 coatings with Fe3O4 NPs offer a promising strategy to enhance the biological performance of percutaneous Ti implants.
- The magnetic properties induced by Fe3O4 NPs positively influence cellular responses and tissue integration.
- These coatings demonstrate antibacterial properties and reduce adverse soft tissue reactions, leading to better implant integration.
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