Related Experiment Video
Updated: Jan 21, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prognostic value of osteopontin expression in esophageal squamous cell carcinoma: A meta-analysis
Yan Wang1, Yuqing Lu2, Wenying Xu3
1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Objective:
To explore the prognostic role of osteopontin (OPN) overexpression in esophageal squamous cell carcinoma (ESCC).
Methods:
The PubMed, EMBASE, The Cochrane Library, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Data (CBM) and VIP databases were searched from the establishment dates of the databases to March 31, 2019, for potentially related studies. Stata 12.0 software was used for statistical analyses, and the hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the correlation of OPN overexpression with the overall survival (OS) and progression-free survival (PFS) of ESCC patients.
Results:
A total of 8 studies involving 811 patients from China or Japan were included. OPN overexpression was demonstrated to be significantly associated with poor OS (HR = 1.86, 95% CI: 1.22-2.83, P = 0.004), with high heterogeneity (I2 = 61.2%, P = 0.012), and poor PFS (HR=1.63, 95% CI: 1.08-2.47, P = 0.020), without heterogeneity (I2 = 0.0%, P = 0.839). Subgroup analysis results were similar to the pooled results.
Conclusion:
OPN overexpression might serve as a promising independent prognostic risk factor in Chinese and Japanese ESCC patients. However, more well-designed studies enrolling more patients are still needed to verify our findings.
Related Concept Videos
Esophageal Varices-I: Introduction
Directing Effect of Substituents: meta-Directing Groups
Cell Specific Gene Expression
Cell Specific Gene Expression
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

