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Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats

Tarique Anwer1, Zafar Ali Alkarbi2, Ali Hassan Najmi2

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Gizan, Saudi Arabia.

Archives of Physiology and Biochemistry
|August 8, 2019
PubMed

Insights

Zingerone effectively manages type-2 diabetes in rats by reducing hyperglycemia and hyperlipidemia. It also improves insulin levels, antioxidant status, and protects pancreatic beta-cells from degeneration.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Endocrinology

Background:

  • Type-2 diabetes is characterized by hyperglycemia, hyperlipidemia, and oxidative stress.
  • Pancreatic beta-cell dysfunction contributes to the progression of type-2 diabetes.

Purpose of the Study:

  • To investigate the therapeutic potential of zingerone in a type-2 diabetic rat model.
  • To evaluate zingerone's effects on glycemic control, lipid profiles, insulin levels, oxidative stress markers, and pancreatic beta-cell histology.

Main Methods:

  • Type-2 diabetic rats were treated with zingerone.
  • Key biochemical parameters including glucose, insulin, lipid profiles (triglycerides, total cholesterol, LDL, VLDL, HDL), and oxidative stress markers (LPO, GSH) were measured.
  • Antioxidant enzyme activities (GPx, GR, GST, SOD, CAT) were assessed.
  • Histopathological examination of pancreatic beta-cells was performed.

Main Results:

  • Zingerone treatment significantly reduced blood glucose and insulin levels.
  • Lipid parameters, including triglycerides and LDL/VLDL cholesterol, were normalized, while HDL cholesterol increased.
  • Zingerone decreased lipid peroxidation (LPO) and restored glutathione (GSH) levels.
  • Activities of antioxidant enzymes (GPx, GR, GST, SOD, CAT) were significantly improved.
  • Histological studies showed minimized degeneration of pancreatic beta-cells in zingerone-treated rats.

Conclusions:

  • Zingerone demonstrates significant potential in managing hyperglycemia and hyperlipidemia associated with type-2 diabetes.
  • Zingerone exerts protective effects on pancreatic beta-cells by mitigating oxidative stress and improving antioxidant capacity.
  • Zingerone is a promising natural compound for the therapeutic intervention of type-2 diabetes.
Keywords:
Zingeronediabetes mellitushyperlipidaemiaoxidative biochemical markersstreptozotocin

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