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Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological

Daniel S La1, Francesco G Salituro1, Gabriel Martinez Botella1

  • 1SAGE Therapeutics , 215 First Street , Cambridge , Massachusetts 02142 , United States.

Journal of Medicinal Chemistry
|August 8, 2019
PubMed
Summary

Neuroactive steroids, like 24(S)-hydroxycholesterol, modulate NMDA receptors. Researchers optimized these compounds, developing SGE-301, which enhances brain function and cognition in preclinical studies.

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