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Updated: Jan 21, 2026
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Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
Published on: May 24, 2022
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Bioactivity evaluation of calcium silicate-based endodontic materials used for apexification
Elif Şeyda Ürkmez1, Arzu Pınar Erdem1
1Department of Pedodontics, Faculty of Dentistry, Istanbul University, Fatih/Istanbul, Turkey.
Summary
Biodentine and ProRoot MTA show higher bioactivity and mineral uptake in root dentine compared to NeoMTA Plus. These materials also enhance dentine fracture resistance, suggesting advantages in apexification.
Area of Science:
- Biomaterials science
- Endodontics
- Dental materials
Background:
- Mineral trioxide aggregate (MTA) and calcium silicate-based cements are used in endodontic apexification.
- Assessing their bioactivity and impact on root dentine is crucial for treatment success.
Purpose of the Study:
- To compare the bioactivity of Biodentine, ProRoot MTA, and NeoMTA Plus.
- To evaluate element uptake by root dentine and its correlation with fracture resistance and interfacial layer thickness.
Main Methods:
- Root dentine specimens were exposed to Biodentine, ProRoot MTA, and NeoMTA Plus in a simulated apex model.
- Element uptake (Ca, Si, Ca/P) and dentine fracture resistance were measured after immersion in corrected simulated body fluid (c-SBF) for 1, 30, and 90 days.
Main Results:
- All materials significantly increased Ca and Si concentrations in root dentine.
- Ca/P and Si concentrations increased over time for all tested materials.
- Dentine fracture resistance was positively correlated with Si, Ca/P values, and interfacial layer thickness for Biodentine and ProRoot MTA.
Conclusions:
- Biodentine and ProRoot MTA exhibit higher biomineralization capacity and positively influence dentine fracture resistance.
- These findings suggest Biodentine and ProRoot MTA may offer greater benefits than NeoMTA Plus in apexification procedures.
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