Related Experiment Video
Updated: Jan 21, 2026
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
17.9K
Multiparametric MRI Evaluation of Complex Ovarian Masses
Veenu Singla1, Kapil Dawadi1, Tulika Singh1
1Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education Research (PGIMER), Chandigarh, India.
Current Problems in Diagnostic Radiology
|August 11, 2019
Summary
Multiparametric MRI, combining diffusion-weighted imaging and dynamic contrast-enhanced MRI, accurately differentiates benign from malignant complex ovarian masses. This advanced imaging approach aids in precise diagnosis and patient management.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Complex ovarian masses require accurate differentiation between benign and malignant conditions for optimal patient management.
- Magnetic Resonance Imaging (MRI) offers advanced techniques for characterizing pelvic lesions.
Purpose of the Study:
- To evaluate the effectiveness of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) in categorizing complex ovarian masses.
- To determine the diagnostic accuracy of multiparametric MRI in distinguishing benign from malignant ovarian neoplasms.
Main Methods:
- A prospective study involving 33 complex ovarian masses analyzed using 1.5 T MRI.
- Acquisition of T1 and T2-weighted sequences, DWI, and DCE-MRI.
- Calculation of apparent diffusion coefficient (ADC) values and pharmacokinetic parameters (e.g., Tmax, SlopeMax) from DCE-MRI, with histopathology as the gold standard.
Main Results:
- Of 33 masses, 20 were benign, 2 borderline, and 11 malignant.
- Diffusion restriction was observed in all malignant and 13 benign masses.
- Significant differences in mean ADC values between malignant and benign masses (81.8% sensitivity, 63.6% specificity). Type III DCE-MRI curves showed 100% specificity for malignancy. Tmax and SlopeMax parameters demonstrated high diagnostic performance.
Conclusions:
- Multiparametric MRI, integrating DWI and DCE-MRI, provides high diagnostic accuracy for stratifying complex ovarian masses.
- The combination of imaging techniques enhances the ability to differentiate benign from malignant ovarian lesions.
Related Concept Videos
01:21Mass Spectrometry: Complex Analysis
1.7K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
1.7K
01:27Ovarian Cycle
3.5K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
3.5K
01:52Atomic Mass
69.6K
Atoms — and the protons, neutrons, and electrons that compose them — are extremely small. For example, a carbon atom weighs less than 2 × 10−23 g. When describing the properties of tiny objects such as atoms, we use appropriately small units of measure, such as the atomic mass unit (amu). The amu was originally defined based on hydrogen, the lightest element, then later in terms of oxygen. Since 1961, it has been defined with regard to the most abundant isotope of carbon, atoms of which...
69.6K
01:54Molar Mass
86.1K
The identity of a substance is defined not only by the types of atoms or ions it contains but by the quantity of each type of atom or ion. For example, water, H2O, and hydrogen peroxide, H2O2, are alike in that their respective molecules are composed of hydrogen and oxygen atoms. However, because a hydrogen peroxide molecule contains two oxygen atoms, as opposed to the water molecule, which has only one, the two substances exhibit very different properties.
86.1K
02:41Protein Complex Assembly
16.7K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.7K
01:57Protein Complexes with Interchangeable Parts
2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K