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Related Experiment Video

Updated: Jan 21, 2026

Evaluation of the Storage Stability of Extracellular Vesicles

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

Extracellular Vesicles: Catching the Light in Zebrafish.

Frederik J Verweij¹, Vincent Hyenne², Guillaume Van Niel¹

¹Institute for Psychiatry and Neuroscience Paris, Hôpital Saint-Anne, Université Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1266, 75015 Paris, France.

Trends in Cell Biology

|August 12, 2019

Summary

Zebrafish embryos allow high-resolution visualization of extracellular vesicles (EVs), aiding the study of their communication and function in vivo. This breakthrough enhances understanding of physiological and pathological EV roles.

Keywords:

circulation exosomes extracellular vesicles high-resolution imaging in vivo zebrafish

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Last Updated: Jan 21, 2026

Evaluation of the Storage Stability of Extracellular Vesicles

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Published on: May 22, 2019

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Published on: February 7, 2019

Isolation of Tissue Extracellular Vesicles from the Liver

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Published on: August 21, 2019

Area of Science:

Cell Biology
Biomedical Imaging
Developmental Biology

Background:

Extracellular vesicles (EVs) are crucial for intercellular communication across organs.
Studying EVs in vivo is challenging due to limitations in imaging resolution and animal models.

Purpose of the Study:

To leverage zebrafish embryos for high-resolution spatiotemporal visualization of endogenous EVs.
To enable simultaneous study of physiological and pathological EVs.
To elucidate the in vivo mechanisms of EV biogenesis, biodistribution, and target cell interactions.

Main Methods:

Utilized zebrafish embryos as a model organism.
Employed advanced light and electron microscopy techniques.
Visualized nanosized extracellular vesicles at unprecedented resolution.

Main Results:

Achieved high-resolution visualization of EVs in a living organism.
Enabled direct observation of EV dynamics and interactions.
Facilitated comparative studies of normal and disease-related EVs.

Conclusions:

Zebrafish embryos provide a powerful platform for studying extracellular vesicle biology in vivo.
This model system significantly advances the understanding of EV roles in health and disease.
The findings pave the way for novel therapeutic strategies targeting EV-mediated processes.