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Updated: Jan 21, 2026
07:16
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
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Clinicopathologic Diagnostic Approach to Aggressive Variant Prostate Cancer
Varsha Manucha1, John Henegan1
1From the Department of Pathology (Dr Manucha) and the Division of Hematology/Oncology, Department of Medicine (Dr Henegan), University of Mississippi Medical Center, Jackson.
Archives of Pathology & Laboratory Medicine
|August 13, 2019
Summary
Aggressive variant prostate cancer (AVPCa) is a challenging diagnosis in metastatic castration-resistant prostate cancer. This review clarifies AVPCa
Area of Science:
- Oncology
- Pathology
- Urologic Oncology
Background:
- Aggressive variant prostate cancer (AVPCa) emerges in some patients with metastatic castration-resistant prostate cancer.
- AVPCa shares clinical and histologic features with other neuroendocrine prostate carcinomas, leading to diagnostic and therapeutic ambiguity.
Purpose of the Study:
- To familiarize pathologists with AVPCa to aid in its detection and research.
- To provide an overview of AVPCa's evolving management strategies.
Main Methods:
- Comprehensive review of the English language scientific literature on AVPCa.
Main Results:
- Summary of key pathologic characteristics of AVPCa.
- Description of current clinical definitions and diagnostic criteria for AVPCa.
- Exploration of the potential role of biomarkers in guiding future AVPCa treatment.
Conclusions:
- Pathologists play a crucial role in identifying and understanding AVPCa.
- Standardized terminology and treatment protocols for AVPCa are still developing.
- Biomarker research holds promise for personalized AVPCa therapies.
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