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Association of Crohn's Disease with Aryl Hydrocarbon Receptor Gene Polymorphisms in Patients from Southeast China

Chao-Qun Wu1, Qian-Ru Lin1, Shi-Jie Ying1

  • 1Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University , Wenzhou , Zhejiang Province , China.

Immunological Investigations
|August 14, 2019
PubMed

Insights

The aryl hydrocarbon receptor (AhR) gene variant rs2158041 may be linked to Crohn's disease (CD) susceptibility in Southeast China. This specific AhR polymorphism was less common in CD patients, particularly those with ileal or stricture CD.

Area of Science:

  • Immunology
  • Genetics
  • Gastroenterology

Background:

  • The aryl hydrocarbon receptor (AhR) is crucial for immune system regulation.
  • Crohn's disease (CD) involves complex genetic and immune factors.
  • Understanding genetic associations can elucidate CD pathogenesis.

Purpose of the Study:

  • To investigate the association between specific aryl hydrocarbon receptor (AhR) gene polymorphisms and Crohn's disease (CD) in a Southeast Chinese population.
  • To identify potential genetic risk factors for CD development and subtypes.

Main Methods:

  • Utilized an improved multiple ligase detection reaction technique.
  • Genotyped three AhR polymorphisms (rs2158041, rs2066853, rs10249788) in 310 CD patients and 573 controls.
  • Performed association and haplotype analyses.

Main Results:

  • The variant allele (T) and genotype (CT+TT) of rs2158041 were significantly less frequent in CD patients compared to controls (p < 0.05).
  • This association remained significant for ileal CD and stricture CD subtypes (p < 0.0083).
  • No significant differences were found for rs2066853 and rs10249788 polymorphisms or their linkage disequilibrium, except for the rs2158041-rs2066853 (TG) haplotype, which was less frequent in CD patients (p < 0.05).

Conclusions:

  • The AhR gene polymorphism rs2158041 may represent a susceptible locus for Crohn's disease.
  • This association is particularly relevant for ileal CD and stricture CD subtypes.
  • Further research into AhR's role in CD pathogenesis is warranted.

Keywords:
Aryl hydrocarbon receptorCrohn’s diseasegenehaplotypepolymorphisms

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