Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

26.9K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
26.9K
What are Lipids?01:38

What are Lipids?

219.1K
Overview
219.1K
Lipid Digestion01:06

Lipid Digestion

98.8K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
98.8K
Accessory Organs01:31

Accessory Organs

73.8K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
73.8K
Structure of Lipids03:38

Structure of Lipids

98.4K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
98.4K
Activation Energy01:26

Activation Energy

86.4K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating inflammatory ILC2s as a biomarker of gastric cancer progression.

bioRxiv : the preprint server for biology·2026
Same author

Parasites trigger epithelial cell crosstalk to drive gut-brain signalling.

Nature·2026
Same author

Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.

Science advances·2026
Same author

TSLP links intestinal nutrient sensing with amplification of the ILC2-tuft cell circuit.

Nature immunology·2025
Same author

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity.

Cell·2025
Same author

RORγt eTACs mediate oral tolerance and Treg induction.

The Journal of experimental medicine·2025
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Transplantation Into the Mouse Ovarian Fat Pad
09:25

Transplantation Into the Mouse Ovarian Fat Pad

Published on: September 7, 2016

11.9K

ILC2s chew the fat.

Roberto R Ricardo-Gonzalez1, Richard M Locksley2,3,4

  • 1Department of Dermatology, University of California, San Francisco, San Francisco, CA.

The Journal of Experimental Medicine
|August 14, 2019
PubMed
Summary
This summary is machine-generated.

Adipose tissue stromal cells support immune cells called ILC2s. These stromal cells promote ILC2 proliferation and activation through direct contact and IL-33 signaling.

More Related Videos

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.3K
Choice and No-Choice Assays for Testing the Resistance of A. thaliana to Chewing Insects
08:24

Choice and No-Choice Assays for Testing the Resistance of A. thaliana to Chewing Insects

Published on: May 14, 2008

17.6K

Related Experiment Videos

Last Updated: Jan 21, 2026

Transplantation Into the Mouse Ovarian Fat Pad
09:25

Transplantation Into the Mouse Ovarian Fat Pad

Published on: September 7, 2016

11.9K
An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.3K
Choice and No-Choice Assays for Testing the Resistance of A. thaliana to Chewing Insects
08:24

Choice and No-Choice Assays for Testing the Resistance of A. thaliana to Chewing Insects

Published on: May 14, 2008

17.6K

Area of Science:

  • Immunology
  • Cell Biology
  • Adipose Tissue Biology

Background:

  • Innate lymphoid cells type 2 (ILC2s) are crucial for tissue homeostasis and immunity.
  • Adipose tissue harbors a unique immune microenvironment, including ILC2s.
  • The interaction between adipose tissue stromal cells and ILC2s is not fully understood.

Purpose of the Study:

  • To investigate the supportive role of adipose tissue multipotent stromal cells (MSCs) on ILC2s.
  • To elucidate the mechanisms by which MSCs influence ILC2 function.

Main Methods:

  • Co-culture systems involving adipose tissue-derived MSCs and ILC2s.
  • Analysis of ILC2 proliferation and activation markers.
  • Investigation of the role of cell-cell contact and cytokine signaling (IL-33).

Main Results:

  • Adipose tissue MSCs significantly promote ILC2 proliferation.
  • MSCs support ILC2s via contact-dependent mechanisms.
  • IL-33, secreted by MSCs, mediates stress-induced activation of ILC2s.

Conclusions:

  • Adipose tissue MSCs provide multifaceted support to resident ILC2s.
  • This interaction involves both direct cell contact and IL-33 signaling.
  • Understanding this crosstalk is vital for comprehending adipose tissue immunity and metabolic health.