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Lupus anticoagulants in children.
1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Annals of Clinical and Laboratory Science
|September 1, 1988
Summary
Acquired inhibitors, known as lupus anticoagulants, are rarely studied in children. This study found these inhibitors are usually temporary and do not cause bleeding or clotting issues in pediatric patients.
Area of Science:
- Pediatric Hematology
- Autoimmune Disorders
- Coagulation Science
Background:
- Limited data exists on acquired inhibitors like lupus anticoagulants in pediatric populations.
- Adult literature extensively covers lupus anticoagulants, but childhood data is scarce.
Purpose of the Study:
- To investigate the clinical and laboratory findings of acquired inhibitors in children.
- To understand the significance and prevalence of these inhibitors in non-hemophiliac pediatric patients.
Main Methods:
- Clinical and laboratory data were collected from seven pediatric patients (3-14 years old) with acquired inhibitors.
- Patients were non-hemophiliac.
Main Results:
- Seven children (4 female, 3 male) developed acquired inhibitors.
- In most cases, the inhibitor was a transient phenomenon.
- The presence of the inhibitor was not associated with bleeding or thrombotic events.
Conclusions:
- Acquired inhibitors in children are uncommon and typically transient.
- These inhibitors generally do not lead to significant clinical manifestations like bleeding or thrombosis in pediatric patients.