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Updated: Jan 20, 2026

A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
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Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS

Christophe Husser1, Erich Koller1, Andreas Brink1

  • 1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Methods in Molecular Biology (Clifton, N.J.)
|August 15, 2019
PubMed

Keywords:
All ion fragmentationColumn switchingHigh resolution mass spectrometryOligonucleotide biotransformationUPLC

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