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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy
Amandine Oudin1, Julie Chauvin2, Laure Gibot3
1Laboratoire des IMRCP, Université de Toulouse, CNRS UMR 5623, Université Paul Sabatier, 118 route de Narbonne, F-31062, Toulouse Cedex 9, France. afmingo@chimie.ups-tlse.fr and Institut Charles Gerhardt Montpellier UMR5253 CNRS-UM-ENSCM, Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier - Bat. 17-cc1702, Place Eugène Bataillon, F-34095 Montpellier Cedex 5, France. vincent.lapinte@umontpellier.fr.
Abstract:
An amphiphilic polymer (CmPOX) based on poly(2-methyl-2-oxazoline) linked to a hydrophobic part composed of an aliphatic chain ending with a photo-active coumarin group has been synthesized. It exhibits the ability of forming small polymeric self-assemblies, typically of ca. 10 nm in size, which were characterized by TEM, cryo-TEM and DLS. The nanocarriers were further formulated to yield photo-crosslinked systems by dimerization of coumarin units of coumarin-functionalized poly(methyl methacrylate) (CmPMMA) and CmPOX. The formed vectors were used to encapsulate Pheophorbide a, a known photosensitizer for photodynamic therapy. Cytotoxicity as well as phototoxicity experiments performed in vitro on human tumor cells revealed the great potential of these nanovectors for photodynamic therapy.
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