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Updated: Jan 20, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Circular RNA Regulation of Myogenesis
Pengpeng Zhang1, Zhe Chao2, Rui Zhang1
1Department of Biotechnology, College of Life Sciences, Xinyang Normal University, Xinyang 464000, China.
Abstract:
Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until recently. In this review, we discussed the putative biogenesis pathways and regulatory functions of circRNAs. Recent studies showed that circRNAs are abundant in skeletal muscle tissue, and their expression levels are regulated during muscle development and aging. We, thus, characterized the expression profile of circRNAs in skeletal muscle and discussed regulatory functions and mechanism-of-action of specific circRNAs in myogenesis. The future investigation into the roles of circRNAs in both physiological and pathological conditions may provide novel insights in skeletal muscle development and provide new therapeutic strategies for muscular diseases.
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