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Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
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Overview of Urethral Reconstruction by Tissue Engineering: Current Strategies, Clinical Status and Future Direction
Zahra Rashidbenam1, Mohd Hafidzul Jasman2, Pezhman Hafez3
11Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, 12th Floor, Clinical Block, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.
Tissue Engineering and Regenerative Medicine
|August 16, 2019
Summary
Tissue engineering offers a promising alternative for treating urethral strictures, overcoming limitations of traditional grafts. The optimal strategy involves using hypoxia-preconditioned mesenchymal stem cells with autologous cells on a synthetic scaffold.
Area of Science:
- Regenerative Medicine
- Urology
- Biomaterials Science
Background:
- Urethral stricture, often caused by scarring, presents treatment challenges.
- Current surgical options like grafts have complications, including infection and stone formation.
- Tissue engineering emerges as a viable alternative to address these limitations.
Purpose of the Study:
- To review strategies and translational status of urethral tissue engineering.
- To propose an optimized combinatory approach for future urethral tissue engineering.
Main Methods:
- Literature review of key articles from 2006-2018.
- Searched PubMed using terms 'urethral stricture' and 'tissue engineering'.
Main Results:
- Autologous cells are comparable to differentiated mesenchymal stem cells for urologic applications.
- Synthetic scaffolds with appropriate porosity and mechanical strength are ideal for urethral tissue engineering.
Conclusions:
- Hypoxia-preconditioned mesenchymal stem cells combined with autologous cells are effective.
- Seeding cells on a pre-vascularized, synthetic, and biodegradable scaffold represents the best strategy for engineering human urethra.
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