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Positron Emission Tomography in Pediatric Neurodegenerative Disorders
1Department of Neurology, NYU School of Medicine, New York, New York.
Pediatric Neurology
|August 17, 2019
Summary
Molecular neuroimaging using positron emission tomography (PET) offers significant potential for diagnosing and understanding pediatric neurodegenerative disorders. Overcoming barriers like sedation and radiation allows for crucial clinical applications and biomarker development in children.
Area of Science:
- Neuroscience
- Radiology
- Pediatrics
Background:
- Positron emission tomography (PET) is underutilized in pediatric neurodegenerative disorders compared to adults.
- Molecular imaging holds untapped potential for elucidating pathophysiology and identifying biomarkers in children.
- Barriers to pediatric PET scans, including sedation and radiation, are manageable.
Purpose of the Study:
- To review the application and findings of PET studies in children with various neurodegenerative disorders over three decades.
- To highlight the clinical utility and potential of PET in managing pediatric neurodegenerative conditions.
- To advocate for expanded insurance reimbursement for PET scans in pediatric neurodegenerative disorders.
Main Methods:
- Review of published positron emission tomographic (PET) studies focusing on pediatric neurodegenerative disorders.
- Analysis of findings across a range of conditions including lysosomal storage diseases, mitochondrial disorders, and metabolic errors.
- Examination of the clinical impact and diagnostic value of PET in pediatric patient populations.
Main Results:
- PET has demonstrated clinical usefulness and contributed to the management of diverse pediatric neurodegenerative diseases.
- Studies encompass conditions like neuronal ceroid lipofuscinoses, juvenile Huntington disease, Wilson disease, and Rett syndrome.
- PET provides valuable insights into disease progression and therapeutic assessment in affected children.
Conclusions:
- Positron emission tomography (PET) is a valuable tool for pediatric neurodegenerative disorders.
- Expanded clinical application and insurance coverage for PET scans in children are warranted.
- Molecular neuroimaging can significantly advance understanding and clinical care for these conditions.
Keywords:
Imaging biomarkersNeuroimagingPET scanningPediatric neurodegenerative disordersReimbursementMore Related Videos
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