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Updated: Jan 20, 2026

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Published on: June 23, 2021
Radiosynthesis of the diastereomerically pure (E)-[11 C]ABP688
Hussein Bdair1,2, I-Huang Tsai3, Kelly Smart4
1McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada.
Abstract:
We report an efficient protocol for the radiosynthesis of diastereomerically pure (E)-[11 C]ABP688, a positron emission tomography (PET) tracer for metabotropic glutamate type 5 (mGlu5) receptor imaging. The protocol reliably provides sterile and pyrogen-free formulation of (E)-[11 C]ABP688 suitable for preclinical and clinical PET imaging with >99% diastereomeric excess (d.e.), >99% overall radiochemical purity (RCP), 14.9 ± 4.3% decay-corrected radiochemical yield (RCY), and 148.86 ± 79.8 GBq/μmol molar activity in 40 minutes from the end of bombardment.
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