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[Hyperthyroidism: acquired cause of an increase in haemoglobin A2 level]
Emmanuelle Stein1, Delphine Gérard1, Philippe Joly2
1Service d'hématologie biologique, Pôle laboratoires, Centre hospitalier universitaire de Nancy, France.
Annales De Biologie Clinique
|August 17, 2019
Summary
Hyperthyroidism can affect blood health, sometimes raising hemoglobin A2 levels. This case links Grave's disease to a potential beta-thalassemia trait in a patient with microcytosis.
Area of Science:
- Hematology
- Endocrinology
- Genetics
Background:
- Hyperthyroidism is linked to various hematological abnormalities.
- Elevated hemoglobin A2 levels can indicate beta-thalassemia trait.
Observation:
- A 29-year-old Mediterranean male presented with microcytosis.
- Hemoglobin analysis revealed a slight increase in hemoglobin A2 levels.
Findings:
- The patient was diagnosed with Grave's disease.
- The elevated hemoglobin A2 was associated with Grave's disease, mimicking beta-thalassemia trait.
Implications:
- This case highlights the importance of considering endocrine disorders in unexplained hematological findings.
- Grave's disease may influence hemoglobin A2 levels, requiring careful differential diagnosis.
- Further research is needed to understand the mechanisms linking hyperthyroidism and hemoglobin A2 variations.
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