[ANALYSIS OF SERUM VEGF LEVEL IN PATIENTS WITH VARICOSE VEINS AFTER ENDOVENOUS LASER ABLATION]

The aim of the study was the analysis of serum VEGF level in patients with varicose veins before and after the endovenous laser ablation (EVLA) and to study the role of VEGF in recurrence of the disease. The research involved 216 persons. The study group included 136 patients with varicose veins. Control group included 80 healthy persons. All 136 persons were treated by endovenous laser ablation. To establish the presence of recurrent veins we conducted several observations of patients in period of 1/2-1-3-6-12 months after the treatment and then every 6 month during 3 years. Serum samples were collected from patients' before the operation and 3-6 month after the operation. Serum VEGF level were significantly higher in study group (86,63 pg/ml) comparing to control group 24.10 pg/ml (р 0,01). Mean level of VEGF before the operation were 86.83 pg/ml and in 3 month after the operation decreased to 24.98 pg/ml (р=0,01). In recurrent cases VEGF level were 3 times higher than in non-recurrent cases (р=0,01). There is a direct correlation of VEGF level and recurrence r=0,40, also direct correlation established between the СЕАР clinical class and VEGF level r=0,64.