Fetal autopsy parameters standards: biometry, organ weights, and long bone lengths

Area of Science:

• Perinatal Medicine
• Forensic Pathology
• Biostatistics

Background:

• Accurate interpretation of fetal and perinatal anthropometric parameters relies on growth charts and tables.
• Population-specific growth standards are crucial for representative data, as parameters vary geographically.
• Existing standards may not accurately reflect local populations, necessitating localized development.

Purpose of the Study:

• To establish comprehensive autopsy-based fetal growth standards for the Portuguese population.
• To develop reference curves for biometrical measurements, organ weights, and long bone lengths.
• To provide a tool for accurate interpretation of autopsy findings in Portuguese fetuses and neonates.

Main Methods:

• Retrospective analysis of autopsy data from Portuguese fetuses and neonates.
• Application of robust statistical regression methodology for mean and standard deviation modeling.
• Construction of growth curves spanning gestational ages from 12 to 42 weeks.

Main Results:

• Development of a complete set of autopsy fetal growth parameters, including biometry, organ weights, and long bone lengths.
• Creation of statistically robust growth curves based on local Portuguese data.
• Establishment of reliable reference standards for fetal autopsy examinations.

Conclusions:

• The developed growth curves provide essential, population-specific standards for fetal autopsy interpretation.
• These standards are particularly valuable for the Portuguese population, enhancing diagnostic accuracy.
• The study contributes to improved understanding and assessment of fetal growth in perinatal and forensic contexts.