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Published on: January 11, 2019
Ag2CO3-Catalyzed H/D Exchange of Five-Membered Heteroarenes at Ambient Temperature
En-Ci Li1, Guang-Qi Hu1, Yu-Xing Zhu1
1Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing Technical University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P.R. China.
Abstract:
Ag2CO3-catalyzed hydrogen isotope exchange of five-membered heteroarenes is disclosed. The reaction can be conducted in the open air, at ambient temperature, and with D2O as deuterium source. Moreover, this protocol showed orthogonal site selectivity to existing technology, thereby greatly expanding the scope of substrates for HIE reaction. The mechanistic study indicated that the carbonate group plays a crucial role to achieve high levels of deuterium incorporation by lowering the activation energy of H/D exchange process.
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