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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
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Sample Preparation for Probe Electrospray Ionization Mass Spectrometry
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Vibrating tip spray ionization mass spectrometry for direct sample analysis.

Ya-Nan Yao1, Lin Wu1, Dandan Di1

  • 1Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Engineering Research Center for Online Source Apportionment System of Air Pollution, Jinan University, Guangzhou, 510632, China.

Journal of Mass Spectrometry : JMS
|August 20, 2019
PubMed
Summary
This summary is machine-generated.

A novel vibrating tip spray ionization source enables direct mass spectrometric analysis of raw samples without voltage. This voltage-free method simplifies analysis for food safety, pharmaceuticals, and forensics.

Keywords:
direct sample analysisfood safetyforensic sciencein vivo analysispharmaceutical analysisvibrating tip spray ionization

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • Direct analysis of raw samples is challenging.
  • Existing methods often require extensive sample preparation and high voltage.

Purpose of the Study:

  • To develop a voltage-free vibrating tip spray ionization source for direct mass spectrometric analysis.
  • To evaluate its performance in various applications.

Main Methods:

  • A vibrating tip spray ionization source was constructed and coupled to a mass spectrometer.
  • Liquid, viscous, and solid samples were analyzed directly after solvent addition.
  • Analyte atomization and ionization were achieved via vibration under ambient conditions.

Main Results:

  • The vibrating tip spray mass spectrometry (VTS-MS) was successfully applied to food safety, pharmaceutical analysis, and forensic science.
  • In situ and in vivo analyses of biological samples were demonstrated.
  • Analytical performance metrics such as sensitivity, reproducibility, and linear range were investigated.

Conclusions:

  • The developed voltage-free vibrating tip spray ionization source offers a versatile and convenient platform for direct mass spectrometric analysis.
  • This technique shows significant potential for diverse applications requiring minimal sample preparation.