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Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1

Yosuke Hashimoto1, Keisuke Tachibana1, Susanne M Krug2

  • 1Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

International Journal of Molecular Sciences
|August 21, 2019
PubMed
Summary

Targeting tight junction (TJ) proteins offers a novel approach to enhance drug delivery and develop new therapies. This review explores claudin and angulin binders for TJ modulation in drug development.

Keywords:
Clostridium perfringens enterotoxinClostridium perfringens iota-toxinangubindin-1angulinantibodyclaudindrug developmenttight junction

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