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Related Experiment Video

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Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells

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[Cylindromas-rare but striking].

C Löser¹, A Rütten², E Dippel³

¹Hautklinik Ludwigshafen, Hauttumorzentrum, Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Bremserstr. 79, 67063, Ludwigshafen, Deutschland. loeserc@klilu.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|August 21, 2019

Summary

This summary is machine-generated.

Cylindromas are rare skin tumors typically affecting the scalp and face. Multiple tumors may indicate Brooke-Spiegler syndrome, and any rapid growth warrants investigation for malignancy.

Keywords:

Adnexal tumor Brooke-Spiegler syndrome Familial cylindromatosis Scalp Turban tumor

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Area of Science:

Dermatology
Oncology

Background:

Cylindromas are uncommon benign neoplasms originating from adnexal structures.
They most frequently occur on the scalp and face.
Multiple cylindromas can be associated with familial Brooke-Spiegler syndrome.

Purpose of the Study:

To describe the clinical presentation and characteristics of cylindromas.
To highlight the association between multiple cylindromas and Brooke-Spiegler syndrome.
To emphasize the importance of monitoring for malignant transformation.

Main Methods:

Review of clinical cases and literature.
Dermatopathological examination.
Genetic analysis for Brooke-Spiegler syndrome (if applicable).

Main Results:

Solitary cylindromas are often incidentally diagnosed.
Multiple cylindromas, especially on the head (turban tumors), suggest Brooke-Spiegler syndrome.
Sudden enlargement or ulceration are concerning signs.

Conclusions:

Cylindromas require careful clinical evaluation, particularly when multiple or presenting with concerning changes.
Suspicion of Brooke-Spiegler syndrome should be raised with multiple lesions.
Malignant transformation, though rare, necessitates vigilance.