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Updated: Jan 20, 2026
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Ultra-long Read Sequencing for Whole Genomic DNA Analysis
Published on: March 15, 2019
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Precision nomenclature for the new genomics.
Harris A Lewin1, Jennifer A Marshall Graves2, Oliver A Ryder3
1Department of Evolution and Ecology and the UC Davis Genome Center, 4321 Genome and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA.
Gigascience
|August 23, 2019
Summary
New terms C-scaffold and scaffotype resolve nomenclature conflicts between cytology and genomics. This standardized terminology aids in classifying genome assemblies for large-scale sequencing projects.
Area of Science:
- Genomics
- Cytology
- Bioinformatics
Background:
- Nomenclature conflicts arise when scientific disciplines merge, necessitating clear terminology.
- Cytology and genomics currently use distinct vocabularies that require reconciliation for accurate communication.
Discussion:
- The proposed terms C-scaffold (for chromosome-scale DNA assemblies) and scaffotype (for an organism's complete genome assembly) address these conflicts.
- This new nomenclature respects historical definitions of 'chromosome' and 'karyotype' while providing precise terms for genomic data.
Key Insights:
- C-scaffold refers to chromosome-scale assemblies of sequenced DNA fragments.
- Scaffotype denotes the collection of C-scaffolds representing an organism's genome.
Outlook:
- Adoption of C-scaffold and scaffotype nomenclature will standardize genome assembly classification.
- This facilitates genomic analysis and data interpretation in large-scale sequencing initiatives.
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