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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Trial and Error and Algorithm01:12

Trial and Error and Algorithm

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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Random Error01:04

Random Error

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Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
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Random Variables01:09

Random Variables

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A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
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Randomized Experiments01:13

Randomized Experiments

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
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Updated: Jan 20, 2026

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
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Dermal suture only versus layered closure: A randomized, split wound comparative effectiveness trial.

Jayne S Joo1, Anne R Zhuang2, Catherine Tchanque-Fossuo3

  • 1Department of Dermatology, University of California Davis Medical Center, Sacramento, California; Sacramento VA Medical Center, Mather, California.

Journal of the American Academy of Dermatology
|August 24, 2019
PubMed
Summary
This summary is machine-generated.

Layered wound closure showed slightly better scar outcomes initially, but differences diminished over time. At 12 months, scar appearance was similar between single-layer and layered techniques, except for color.

Keywords:
scarskin surgerysuture techniquewound closure

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Wound Healing Research

Background:

  • Layered closure is standard for cutaneous wounds.
  • Epidermal sutures may be unnecessary in some cases.

Purpose of the Study:

  • Compare scar outcomes of single-layer deep-dermal vs. conventional layered suture techniques.
  • Evaluate scar quality using the Patient and Observer Scar Assessment Scale (POSAS).

Main Methods:

  • Prospective, randomized, evaluator-blinded, split scar study.
  • 49 patients enrolled.
  • Comparison of bilayered closure with single-layer deep-dermal suturing.

Main Results:

  • At 3 months, layered closure showed statistically significant preference (POSAS scores).
  • At 12 months, scar outcome differences diminished.
  • Scar color was more noticeable with single-layer dermal sutures at 12 months.

Conclusions:

  • Layered closure offers a slight scar improvement at 3 months.
  • Scar appearance becomes similar by 12 months.
  • Single-layer deep-dermal closure is a viable alternative with comparable long-term scar outcomes.