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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
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Quantative HBsAg level correlates dendritic cells maturation in chronic hepatitis B patients
Xiaoyan Li1, Liang Zhou2, Yurong Gu1
1Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Clinics and Research in Hepatology and Gastroenterology
|August 28, 2019
Summary
Entecavir treatment for Chronic Hepatitis B (CHB) restores dendritic cell (DC) frequencies and improves their maturation. High baseline Hepatitis B surface antigen (HBsAg) levels impact DC function, highlighting HBsAg
Area of Science:
- Immunology
- Hepatology
- Virology
Background:
- Chronic Hepatitis B (CHB) is associated with altered immune cell function.
- Dendritic cells (DCs) play a crucial role in immune responses.
- The specific role of DCs in CHB pathogenesis and treatment remains to be fully elucidated.
Purpose of the Study:
- To investigate the frequencies and maturation markers of dendritic cells (DCs) in patients with Chronic Hepatitis B (CHB).
- To evaluate the changes in DC populations and maturation during entecavir (ETV) treatment.
- To determine the correlation between baseline Hepatitis B surface antigen (HBsAg) levels and DC status.
Main Methods:
- Flow cytometry analysis of blood samples from 26 CHB patients.
- Assessment of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) frequencies.
- Evaluation of DC maturation markers and HBsAg levels at baseline and during 48 weeks of ETV treatment.
Main Results:
- CHB patients exhibited lower baseline frequencies of mDCs and pDCs compared to healthy controls.
- Entecavir treatment led to increased pDC frequencies and enhanced mDC maturation markers.
- Higher baseline HBsAg levels correlated with poorer DC maturation, irrespective of treatment-induced HBsAg changes.
Conclusions:
- Entecavir therapy can restore DC frequencies and improve DC maturation in CHB patients.
- Baseline HBsAg levels are a significant factor influencing DC function in CHB.
- These findings suggest DCs as potential therapeutic targets and biomarkers in CHB management.
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