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Published on: May 26, 2023
Office-based corticosteroid injections as adjuvant therapy for subglottic stenosis
1Department of Otolaryngology University of Miami Miller School of Medicine Miami Florida U.S.A.
Subglottic stenosis (SGS) treatment improved with corticosteroid injections. Office-based steroid injections significantly increased surgery-free intervals (SFIs) in SGS patients, offering a promising adjuvant therapy.
Area of Science:
- Otolaryngology
- Pulmonology
- Medical Innovation
Background:
- Subglottic stenosis (SGS) presents significant treatment challenges due to high recurrence rates.
- Conventional management relies on serial endoscopic dilation, often with limited long-term success.
Purpose of the Study:
- To evaluate the efficacy of subglottic corticosteroid injections as an adjuvant therapy for SGS.
- To determine if these injections can increase surgery-free intervals (SFIs) in patients with SGS.
Main Methods:
- Retrospective chart review of SGS patients undergoing endoscopic dilation and office-based steroid injections (SILSI).
- Calculation and comparison of SFIs before and after SILSI initiation.
- Statistical analysis using Mann-Whitney U test to assess significance (P < .05).
Main Results:
- Thirteen patients (mean age 50.1 years; 7:6 female:male) were included.
- The mean SFI significantly increased from 288.6 days before SILSI to 545.5 days after SILSI (P = .0041).
- Intubation-related stenosis was the most common cause (61.5%).
Conclusions:
- Office-based corticosteroid injections are associated with a statistically significant improvement in SFIs for SGS.
- SILSI represents a promising adjuvant treatment approach for managing subglottic stenosis.
- Further prospective studies are warranted to confirm efficacy and guide integration into standard care.
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