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In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
Published on: June 28, 2019
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
Marianne Bore Haarr1, Emil Lindbäck1, Torfinn Håland2
1Faculty of Science and Technology, Department of Mathematics and Natural Sciences, University of Stavanger, NO-4036 Stavanger, Norway.
Abstract:
N 1,N 3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from 5-acetamido-N 1,N 3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (2), has been successfully prepared with an overall yield of 25%. Epoxide 1 enabled the confirmation of its presence in the reaction mixture during the preparation of iodixanol when amide 2 was used as the starting material.
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