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Updated: Jan 20, 2026
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives
Xingxing Ma1, Qiuling Song1,2,3
1Institute of Next Generation Matter Transformation, College of Materials Science & Engineering , Huaqiao University , 668 Jimei Blvd , Xiamen , Fujian 361021 , China.
Abstract:
A tert-butyl nitrite (TBN)-mediated synthesis of fluorinated O-alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. A variety of halodifluorinated compounds were found compatible, delivering the desired products in moderate to excellent yields. This transformation features a simple operation, can be done in air, and found to involve radicals. This protocol represents a straightforward approach to access various fluorinated O-alkyloxime ether derivatives.
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