Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: A review

Polybrominated diphenyl ethers (PBDEs) are widely used as brominated flame retardants. Because of their toxicity and persistence, some PBDEs were restricted under the Stockholm Convention in 2009. Since then, many studies have been carried out on PBDEs in China and in many other countries. In the present review, the occurrences and contamination of PBDEs in air, water, sediment, soil, biota and daily food, human blood, hair, and other human tissues in China are comprehensively reviewed and described. The human exposure pathways and associated health risks of PBDEs are summarized. The data showed no obvious differences between North and South China, but concentrations from West China were generally lower than in East China, which can be mainly attributed to the production and widespread use of PBDEs in eastern regions. High levels of PBDEs were generally observed in the PBDE production facilities (e.g., Jiangsu Province and Shandong Province, East China) and e-waste recycling sites (Taizhou City, Zhejiang Province, East China, and Guiyu City and Qingyuan City, both located in Guangdong Province, South China) and large cities, whereas low levels were detected in rural and less-developed areas, especially in remote regions such as the Tibetan Plateau. Deca-BDE is generally the major congener. Existing problems for PBDE investigations in China are revealed, and further studies are also discussed and anticipated. In particular, non-invasive matrices such as hair should be more thoroughly studied; more accurate estimations of human exposure and health risks should be performed, such as adding bioaccessibility or bioavailability to human exposure assessments; and the degradation products and metabolites of PBDEs in human bodies should receive more attention. More investigations should be carried out to evaluate the quantitative relationships between internal and external exposure so as to provide a scientific basis for ensuring human health.