Related Experiment Video
Updated: Jan 20, 2026
Somatic Stem cells in Tissue Repair and Regeneration
Published on: April 30, 2023
Evaluation of Biocompatibility of Different Membrane Surfaces Using Unrestricted Somatic Stem Cells
Lara Schorn1, Jörg Handschel2, Julian Lommen1
1Department of Oral-, Maxillo- and Plastic Facial Surgery, Heinrich-Heine-University and University Hospital Duesseldorf, Duesseldorf, Germany.
Background/Aim:
Results of Guided Bone Regeneration (GBR) primarily depend on the membrane used. The aim of this study was to compare biocompatibility of different absorbable and non-absorbable membranes by using unrestricted somatic stem cells (USSCs) as an indicator for biocompatibility.
Materials And Methods:
Five absorbable membranes (Bio-Gide®, RESODONT®, GENTA-FOIL resorb®, BioMend® and BioMend® Extend™) and one non-absorbable alternative (GORE-TEX®) were colonized with USSCs. After 24 h, 3 days and 7 days, cell proliferation, cell viability, and cytotoxicity were assessed. Moreover, cell morphology was evaluated by electron microscopy.
Results:
Significantly higher cell proliferation and cell viability rates were observed in Bio-Gide® and RESODONT® membranes. Cell toxicity was highest on GENTA-FOIL resorb® membranes. The electron microscopical assessment showed a better cell attachment on porous surfaced membranes.
Conclusion:
This study shows that USSCs can be used for assessments of biocompatibility, and that absorbable membranes with collagenous composition and porous structure tend to positively impact biocompatibility and enhance cell proliferation.
Related Concept Videos
Tissue Regeneration with Somatic Stem Cells
This video first defines somatic stem cells, and then explores the role these cells play in tissue regeneration....
13:05De Novo Generation of Somatic Stem Cells by YAP/TAZ
09:43Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus
11:39Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
07:57Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

