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Updated: Jan 20, 2026

Three-Dimensional Thymic Culture System to Generate iPSC-Derived Thymic Emigrants
Paraneoplastic Dermatomyositis as a Potential Precursor to Thymic Carcinoma
Takehiro Tsuchiya1, Atsushi Sano1, Mitsuaki Kawashima1
1Department of Thoracic Surgery, Chigasaki Municipal Hospital, Chigasaki, Kanagawa, Japan.
Abstract:
A red rash developed on both hands of a 54-year-old man. At age 56, he was admitted to our hospital because of an abnormal shadow detected by chest roentgenogram. A detailed examination revealed an anterior mediastinal tumor and dermatomyositis. Thymectomy was performed, and pathologic examination revealed thymic carcinoma. After the surgery, the dermatomyositis symptoms improved. Although dermatomyositis associated with thymic carcinoma is extremely rare, we should account for the possibility of thymic carcinoma-associated dermatomyositis. This will allow for early identification and treatment of malignant tumors, and symptom severity may reflect the degree disease control.
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