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Updated: Jan 20, 2026

Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
Published on: May 5, 2021
Self-assembly and Cycling of a Three-state Pdx Ly Metallosupramolecular System
Dan Preston1,2, Amanda R Inglis1, James D Crowley3,4
1School of Physical and Chemical Sciences, University of Canterbury, Christchurch, 8041, New Zealand.
Abstract:
The use of stimuli to induce reversible structural transformations in metallosupramolecular systems is of keen interest to chemists seeking to mimic the way that Nature effects conformational changes in biological machinery. While a wide array of stimuli have been deployed towards this end, stoichiometric changes have only been explored in a handful of examples. Furthermore, switching has generally been between only two distinct states. Here we use a simple 2-(1-(pyridine-4-methyl)-1H-1,2,3-triazol-4-yl)pyridine "click" ligand in combination with PdII in various stoichiometries and concentrations to quantitatively access and cycle between three distinct species: a [PdL2 ]2+ monomer, a [Pd2 L2 ]4+ dimer, and a [Pd9 L12 ]18+ cage.
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