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Updated: Jan 20, 2026

In Vivo 2-Photon Calcium Imaging in Layer 2/3 of Mice
Published on: March 13, 2008
Cp*Co(III)-Catalyzed Dearomative [3 + 2] Spiroannulation of 2-Alkenylphenols with Ynamides via C-H Activation
Peng-Peng Lin1, Xiang-Lei Han1, Guo-Hua Ye2
1School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , China.
Abstract:
An oxidative [3 + 2] C-H spiroannulation reaction of 2-alkenylphenols with ynamides has been developed toward the synthesis of spiro[4,5]decane derivatives. This dearomative reaction employs earth-abundant cobalt as the metal catalyst and occurs under rather mild reaction conditions (room temperature). The use of ynamides confers unique reactivity and exclusive regioselectivity. The products bearing an all-carbon quaternary stereogenic center were constructed in generally good yields with good functional group tolerance being observed. Experimental mechanistic studies were conducted, and a possible reaction mechanism is proposed.
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