Related Experiment Video
Updated: Jan 19, 2026
Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction
Published on: April 30, 2023
Monodentate Transient Directing Group Assisted Pd-Catalyzed Direct Dehydrogenative Cross-Coupling of Benzaldehydes
Yi-Feng Wang1, Wen-Gang Xu1, Bing Sun1
1School of Chemistry, Chemical Engineering and Life Sciences , Wuhan University of Technology , Wuhan 430070 , P.R. China.
Abstract:
Commercially available 3,5-bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes. A diverse set of symmetrical and unsymmetrical 9-fluorenones was readily obtained in yields of 32-72% along with excellent regioselectivities and broad functional group compatibility as well as high atom economy under mild conditions via a dual carbon-hydrogen (C-H) bond activation sequence.
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Palladium-Catalyzed Cross Coupling
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