Dexmedetomidine versus sufentanil with high- or low-concentration ropivacaine for labor epidural analgesia: A...

To study analgesic effects of dexmedetomidine or sufentanil, both combined with ropivacaine, in epidural analgesia during labor.

We recruited 160 primigravidae with full-term pregnancy who received epidural anesthesia during labor and randomized them into four groups to receive epidural administration of ropivacaine combined with sufentanil (RS₁ and RS₂ groups) or with dexmedetomidine (RD₁ and RD₂ groups). Systolic blood pressure, diastolic blood pressure and heart rate before anesthesia (T₁ ), 15 min after anesthesia induction (T₂ ), on delivery (T₃ ) and 2 h postpartum (T₄ ), together with visual analogue scale scores, Bromage scores, Ramsay scores, adverse reactions during analgesia and urinary retention at 6 and 24 h postpartum were recorded; the pH, PCO₂ and PO₂ of umbilical cord arterial blood and Apgar scores at 1, 5 and 10 min after childbirth were assessed.

RS₁ group had significantly lower systolic blood pressure, diastolic blood pressure and heart rate than RD₁ group at T₂ and T₃ (all P < 0.05), but not at T1. At T₂ and T₃ , the other three groups were lower than RS₂ group in visual analogue scale and Ramsay scores (all P < 0.05). After childbirth, RD₂ group had significantly higher PO₂ result than other three groups (P < 0.05). At 6 h postpartum, RD₂ group had significantly fewer cases of urinary retention than RD₁ and RS₁ groups (both P < 0.05).

A relatively low concentration of ropivacaine, combined with dexmedetomidine, is better in analgesia during labor.