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Updated: Jan 19, 2026
Factors Affecting Renal Clearance: Renal Impairment
Ceftaroline-associated Encephalopathy in Patients With Severe Renal Impairment
Thomas C S Martin1, Sean Chow2, Scott T Johns2
1Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California.
Abstract:
Encephalopathy complicates beta-lactam therapy, particularly with impaired renal function, though no studies have reported ceftaroline-associated encephalopathy. Among 28 patients with estimated glomerular filtration rates <30 mL/min who received ≥5 days of ceftaroline, 3 developed encephalopathy. Ceftaroline, when dosed supra-therapeutically for serious infections, may be a cause of antibiotic-associated encephalopathy.
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