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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

47
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
47

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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
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Successful Control of Refractory Coccidioides Meningitis With MAT2203.

Sanjay R Mehta1,2, Scott Johns3, Theresa Matkovits4

  • 1Department of Medicine, San Diego Veterans Affairs Medical Center, San Diego, California, USA.

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Summary

Refractory Coccidioides meningitis can be challenging to treat. Oral MAT2203, a novel amphotericin B formulation, achieved undetectable Coccidioides antigen in a patient with severe, refractory meningitis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neuroscience

Background:

  • Coccidioides meningitis is a severe complication requiring lifelong antifungal therapy.
Keywords:
CoccidioidesLNC amphotericinMAT2203meningitisoral amphotericin

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  • Treatment often involves azoles or intravenous/intrathecal amphotericin B for refractory cases.
  • MAT2203 is an orally absorbed amphotericin B formulation with prior success in cryptococcal and histoplasmic meningitis.