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Updated: Jan 19, 2026
Assessing Bone Mineral Density Using Radiofrequency Echographic Multi-Spectrometry
Published on: January 15, 2026
Unexpected rapid increase in bone mineral density by bisphosphonate therapy after multiple spinal fractures: a case
Hidefumi Koiwai1, Mikio Kamimura2, Jun Takahashi3
1Koiwai Orthopedic Clinic, Mikageshinden 1585-4, Komoro, 384-0091, Japan.
Background:
Osteoporosis is a serious disease that causes bone fragility fractures and increases mortality. Bisphosphonates are the first-line drugs for osteoporosis. However, the gains in bone mineral density by use of bisphosphonates alone are limited.
Case Presentation:
We describe the clinical outcome of a Japanese woman with osteoporosis treated with bisphosphonates after multiple spinal fractures. After 3 years of treatment with the bisphosphonate alendronate, her lumbar bone mineral density and bilateral hip bone mineral density markedly increased by 61.9% and 32.5%, respectively.
Conclusion:
We considered that our patient's multiple fractures had caused a decrease in bone mineral density, which naturally improved with fracture healing to enhance the increase in bone mineral density with bisphosphonate treatment.
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