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Updated: Jan 19, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Construction of All-Carbon Quaternary Stereocenters via Sequential Photoactivation/Isothiourea Catalysis
Tao Fan1, Zi-Jing Zhang1, Yu-Chen Zhang1
1Department of Chemistry , University of Science and Technology of China , Hefei , 230026 , China.
Abstract:
Highly enantioselective [4 + 2] cyclizations of azadienes with in situ generated ketenes were developed through sequential visible-light photoactivation/isothiourea catalysis, which offers a novel approach for the creation of all-carbon quaternary stereocenters through disubstituted C1-ammonium enolates. The visible-light-induced sustained release of reactive ketene species through Wolff rearrangement of α-diazoketones is crucial for achieving high levels of chemical efficiency and stereoinduction.
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