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Published on: May 18, 2016
Late infra-renal aortic graft infection: a fearsome complication
Fernando Peixoto Ferraz de Campos1, Erasmo Simão Silva2, Nelson De Luccia2
1Department of Internal Medicine - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil.
Abstract:
Since the 1950s, aortic graft infections (AGIs) constitute one of the most feared complications after reconstructive vascular surgery. This complication is not frequent, ranging from 1% to 2% in the recently reported series; however, the high rate of death and morbidity after therapeutic attempts justifies its dreadful fame. The majority of cases occur during the first month after surgery. Staphylococcus aureus is the cause of 70% of the early infection cases. Late infections, on the other hand, are even rarer, showing a strong relationship with low virulence microorganisms, where Staphylococcus epidermidis is the main cause. Gram-negative bacteria are also observed in late infections, mainly when an aortic or graft enteric fistula is present. Treatment modalities are plenty, but still debatable. The authors report a case of a woman who was operated on 6 years ago for a reconstructive aortic aneurysm with the implantation of an infrarenal Dacron graft in the aorto bifemoral position. She looked for medical assistance with a 2-month history of weight loss, abdominal/back pain, and fever. Her clinical status rapidly deteriorated. A computed tomography of the abdomen disclosed the diagnosis of an AGI. The patient was promptly treated with antibiotics. Surgery was undertaken to explant the infected graft and another graft was placed into the axillobifemoral position. Culture from the infections site was negative. After surgery the patient quickly developed refractory septic shock and died immediately post-operatively.
Insights
Aortic graft infections (AGIs) are rare but serious complications following vascular surgery. This case highlights a fatal outcome despite prompt treatment for a late-onset AGI.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Medical Microbiology
Background:
- Aortic graft infections (AGIs) are a feared complication of reconstructive vascular surgery, occurring in 1-2% of cases.
- Early AGIs (within 1 month) are often caused by Staphylococcus aureus, while late infections involve lower virulence organisms like Staphylococcus epidermidis or Gram-negative bacteria.
Observation:
- A patient with a history of aortic aneurysm repair presented with symptoms of weight loss, pain, and fever.
- Computed tomography confirmed an aortic graft infection (AGI).
Findings:
- Despite prompt antibiotic treatment and surgical explantation of the infected graft, the patient developed refractory septic shock and died post-operatively.
- Intraoperative cultures from the infection site were negative.
Implications:
- This case underscores the high morbidity and mortality associated with AGIs, even with aggressive management.
- Challenges in diagnosing and treating late-onset AGIs, particularly when cultures are negative, require further investigation.
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