Left ventricular dysfunction postsurgical patent ductus arteriosus ligation in children: predictor factors analysis

Area of Science:

• Pediatric Cardiology
• Congenital Heart Disease
• Echocardiography

Background:

• Patent ductus arteriosus (PDA) is a common congenital heart defect in children.
• Surgical closure of PDA leads to significant hemodynamic changes.
• Understanding these changes is crucial for patient management.

Purpose of the Study:

• To identify predictors of left ventricular (LV) dysfunction after PDA surgical ligation.
• To assess the impact of PDA ligation on LV systolic function.
• To establish monitoring guidelines for post-ligation LV function.

Main Methods:

• Retrospective study of 50 children with isolated PDA undergoing surgical ligation.
• Two-dimensional echocardiography used to assess LV dimensions and systolic function pre- and post-ligation.
• Follow-up at 1 day, 1 month, and 6 months post-surgery.

Main Results:

• LV dimensions and systolic function (EF, FS) decreased significantly by day 1 post-ligation.
• Further decreases in LVEDd and LA/Ao observed at 1 month, with gradual improvement in EF and FS.
• PDA size, patient age, preoperative LVEDd, and FS were identified as predictors.

Conclusions:

• PDA ligation is associated with early and significant LV systolic dysfunction.
• This dysfunction may necessitate anti-failure measures and prolonged monitoring.
• Preoperative factors like PDA size and LV function can predict the severity of post-ligation dysfunction.