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Frequency Of Elevated Troponin T In Patients Of Hronic Renal Failure Without Clinically Suspected Acute Myocardial

Syed Affan Ali1, Sumera Kazmi1, Mir Jalal-Ud-Din2

  • 1Department of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|September 20, 2019
PubMed

Insights

Elevated Troponin T is common in chronic renal failure (CRF) patients without acute myocardial infarction, with nearly 40% showing higher levels. This elevation is significantly linked to the stage of kidney disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Biochemistry

Background:

  • Cardiac Troponins are key indicators of myocardial injury.
  • Elevated Troponin T levels can occur in chronic renal failure (CRF) patients independent of acute myocardial infarction.
  • Understanding Troponin T elevation in CRF is crucial for accurate diagnosis.

Purpose of the Study:

  • To determine the frequency of elevated Troponin T in CRF patients without clinically suspected acute myocardial infarction.
  • To investigate the association between elevated Troponin T and the stage of chronic renal failure.

Main Methods:

  • A cross-sectional study involving 117 CRF patients was conducted.
  • Patients with other causes of elevated Troponin T (e.g., ischemia, sepsis, heart failure, cardiotoxic chemotherapy) were excluded.
  • Glomerular filtration rate (GFR) was estimated to define and stage CRF.

Main Results:

  • Out of 117 participants, 45 (38.5%) had elevated Troponin T.
  • A significant association was observed between the stage of CRF and elevated Troponin T levels.
  • A statistically significant negative correlation (r=-0.213, p=0.021) was found between GFR and serum Troponin T levels.

Conclusions:

  • A high proportion of chronic renal failure patients exhibit elevated Troponin T.
  • The elevation of Troponin T in CRF patients is significantly associated with the stage of renal failure.
Abstract

Keywords:
Acute myocardial infarctionChronic renal failure, Troponin T

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