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Efficient engineered probiotics using synthetic biology approaches: A review
Monika Yadav1, Pratyoosh Shukla1
1Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, India.
Biotechnology and Applied Biochemistry
|September 21, 2019
Summary
Synthetic biology enhances probiotics for better health supplements. This review explores genetic engineering and metabolic optimization for improved probiotic strains and future development challenges.
Area of Science:
- Microbiology
- Synthetic Biology
- Biotechnology
Background:
- Probiotics are increasingly recognized for their health benefits, necessitating a deeper understanding of their genetic makeup.
- Probiotic functional parameters are controlled by metabolic functions, requiring optimization for therapeutic applications.
Purpose of the Study:
- To review synthetic biology applications for optimizing probiotic metabolic processes.
- To explore engineered probiotics for use as supplements in allopathic medicine.
Main Methods:
- Compilation of synthetic biology strategies for probiotic metabolic pathway analysis.
- Discussion of genetic circuits, expression systems, and genome editing tools (CRISPR-Cas, PEVLAB) for strain improvement.
Main Results:
- Synthetic biology offers insights into biosynthetic pathways.
- Novel metabolic engineering approaches facilitate probiotic strain enhancement.
Conclusions:
- Engineered probiotics hold significant potential for health supplements.
- Future challenges in developing advanced engineered probiotics are highlighted.
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