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Associations between poor sleep and glucose intolerance in prediabetes
Ibasaraboh D Iyegha1, Angela Y Chieh1, Bianca M Bryant1
1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, United States of America.
Psychoneuroendocrinology
|September 24, 2019
Summary
Poor sleep is common in prediabetes and linked to higher C-reactive protein (CRP) levels. Evaluating sleep quality is crucial for preventing diabetes onset in at-risk individuals.
Area of Science:
- Endocrinology
- Sleep Medicine
- Metabolic Health
Background:
- Prediabetes affects a significant portion of the population, increasing diabetes risk.
- Sleep disturbances are increasingly recognized as a potential factor in metabolic dysregulation.
- Understanding the link between sleep quality and glucose metabolism is vital for public health.
Purpose of the Study:
- To investigate the association between sleep quality and glucose metabolism in individuals with prediabetes.
- To explore potential mechanisms, such as inflammation, linking poor sleep to glucose intolerance.
- To assess the prevalence of poor sleep in prediabetic individuals compared to a normal glucose group.
Main Methods:
- A cross-sectional study involving 155 participants (aged 19-70) with prediabetes and a control group.
- Sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI).
- Glucose metabolism evaluated via oral glucose tolerance test (OGTT); inflammatory markers (CRP, IL-6, IL-8, IL-10, TNFα) measured.
Main Results:
- Individuals with prediabetes reported poorer sleep quality more frequently (62%) than controls (46%).
- Higher C-reactive protein (CRP) levels were observed in the prediabetes group.
- Sleep disturbance positively correlated with CRP levels, and sleep disturbance predicted CRP, even after adjusting for covariates.
Conclusions:
- Prediabetes is associated with poorer sleep quality.
- Elevated CRP levels may mediate the relationship between prediabetes and poor sleep.
- Clinicians should assess sleep quality in prediabetes management to aid in diabetes prevention.
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