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Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
Published on: June 1, 2011
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Electrochemical DNA Biosensors Based on Labeling with Nanoparticles
1Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece. christok@chem.uoa.gr.
Nanomaterials (Basel, Switzerland)
|September 25, 2019
Summary
Electrochemical DNA biosensors utilize nanoparticle labels for ultrasensitive detection. This review highlights advances in voltammetric determination of these nanotags for low-cost, integrated biodevices.
Area of Science:
- Electrochemistry
- Nanotechnology
- Biosensing
Background:
- DNA biosensors are crucial for diagnostics.
- Nanoparticle labels offer enhanced detection sensitivity.
- Electrochemical methods provide sensitive and cost-effective analysis.
Purpose of the Study:
- To review electrochemical DNA biosensors employing nanoparticle labels.
- To discuss advances in voltammetric determination of nanotags.
- To cover integrated biodevices and multiplexing strategies.
Main Methods:
- Utilizing metal nanoparticles (NPs) or quantum dots (QDs) as labels.
- Electrochemical determination via pulse voltammetry (PV) and stripping voltammetry (SV).
- Oxidation of nanotags to ions for quantification.
Main Results:
- Ultrasensitive, low-cost, and miniaturized DNA biosensors achieved.
- Demonstrated effectiveness of gold/silver NPs and Cd/Pb-based QDs.
- Successful integration into three-electrode and paper-based systems.
Conclusions:
- Electrochemical determination of nanoparticle labels enables highly sensitive DNA detection.
- Nanoparticle-based electrochemical DNA biosensors are promising for various applications.
- Further development in integrated systems and multiplexing is ongoing.
