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Cardiac troponin I in cats with compromised renal function
Rebecca Langhorn1, Lisbeth R Jessen1, Anne S Kloster1
1Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Journal of Feline Medicine and Surgery
|September 26, 2019
Summary
Serum cardiac troponin I (cTnI) can be elevated in cats with kidney disease, even without heart problems. Urine cTnI is also more detectable in cats with kidney dysfunction.
Area of Science:
- Veterinary Cardiology
- Nephrology
- Biomarker Research
Background:
- Cardiac troponins (cTnI) are key indicators of heart muscle damage.
- Concerns exist regarding cTnI reliability in renal disease due to potential kidney involvement in its clearance.
Purpose of the Study:
- To determine if serum cTnI is elevated in cats with kidney dysfunction but no structural heart disease.
- To assess the detectability of cTnI in the urine of cats with normal and impaired renal function.
Main Methods:
- A prospective case-control study involving 52 cats (19 renal, 19 cardiac, 14 controls).
- Comprehensive diagnostics including clinical exams, echocardiography, ECG, blood pressure, CBC, biochemistry, thyroxine, and urinalysis.
- Serum and urine cTnI levels were measured in all cats.
Main Results:
- Cats with renal disease and cardiac disease showed significantly higher serum cTnI than controls.
- No significant difference in serum cTnI was found between renal and cardiac groups.
- Urine cTnI was measurable in 7/19 cats with renal disease, compared to 1/19 cardiac and 2/14 controls.
Conclusions:
- Elevated serum cTnI in cats with renal disease can occur independently of significant structural cardiac disease.
- Urinary cTnI detection is more probable in cats experiencing renal dysfunction.
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